9/4/2023 0 Comments Cataplexy symptomsWhile there’s currently no cure for narcolepsy, several treatments are available that can help you manage symptoms and overall well-being. Many people with narcolepsy report that their sleepiness and cataplexy significantly interfere with their daily lives, including in school, work, relationships, and their social life. If you’ve had a tumor or other disease in this same brain region, you may also develop secondary narcolepsy. This figure includes people who experience secondary narcolepsy - narcolepsy due to an underlying illness or condition.įor instance, traumatic brain injury to the hypothalamus may cause narcolepsy in some people. These symptoms include:Īround 65 per 100,000 people are believed to have type 2 narcolepsy. You won’t experience muscle weakness in type 2.īut in general, symptoms of type 2 narcolepsy are very similar to type 1. The main difference between the types is the presence of cataplexy. But it is possible that the cataplexy symptoms just weren’t recognized before. Some experts believe type 2 narcolepsy could be a precursor to type 1 narcolepsy, since some people go on to develop cataplexy later in life. People with this type of narcolepsy don’t experience cataplexy or have low levels of hypocretin. The precise cause of type 2 narcolepsy remains unknown. Type 2 narcolepsy was previously called narcolepsy without cataplexy. Some people can start having symptoms in early childhood, though it’s commonly misdiagnosed as ADHD or behavioral problems. Most people start having symptoms in their late teens or early 20s. But this doesn’t account for everyone who might have narcolepsy but are either misdiagnosed or undiagnosed. You may also have co-occurring sleep disorders, such as insomnia, obstructive sleep apnea, and periodic leg movements.Īnyone with narcolepsy may also experience:Īccording to a 2019 study, 14 per 100,000 people are diagnosed with type 1 narcolepsy. When they happen while falling asleep, they’re called hypnagogic hallucinations. When they happen upon waking, they’re called hypnopompic hallucinations. Vivid visual hallucinations usually occur at the beginning or end of the sleep cycle. When you experience sleep paralysis, you’re temporarily unable to move or speak while falling asleep or waking up. There’s no loss of consciousness during an episode of cataplexy. It may last a few seconds or several minutes while you’re awake. Cataplexy is when you experience sudden muscle weakness. In addition, 10–25% of individuals with type 1 narcolepsy have these other symptoms: You may have several attacks during a single day. The main symptom of narcolepsy is EDS, regardless if it’s type 1 or 2.Īttacks of excessive daytime sleepiness can last a few seconds to several minutes and vary in frequency. Some evidence suggests that the HLA-DQB1-0602 gene is present in a majority of people with type 1 narcolepsy who have cataplexy and hypocretin deficiency.Īlthough this gene explanation is widely accepted, it’s still not fully proven and more research is needed. However, genetic factors may play an important role. Researchers don’t fully understand why this is, but believe that some sort of autoimmune condition could be the cause. Hypocretin, also known as orexin, is a chemical that helps regulate wakefulness and sleep.Īccording to research in 2017, people with type 1 narcolepsy have a loss of up to 95% of hypocretin-producing neurons in the part of the brain called the lateral hypothalamus. Narcolepsy type 1 occurs when nearly all neurons containing hypocretin are lost. Narcolepsy with cataplexy is known as narcolepsy type 1.
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